The Centre was opened on 6 September 1976 with 28 trained women on roster for limited phone counselling. By 1980 they had 40 volunteers and 2 part time co ordinators. These workers and volunteers took on roles in counselling services, community education, administration, the Management Committee, Liason Committee and the sexual assult clinic. They trained other services who helped women and girls who had been raped or sexually assulted.

Initially the Rape Crisis Centre operated at Mary St, Hindmarsh. The service then moved to the Queen Elizabeth Hospital and on to North Adelaide where it became Yarrow Place. The centre has produced a newsletter since 1977 which is now online.

Some of the women involved include Heather Crosby, Myra Williams (Betschild), Silver Moon, Helen Oxenham, Jenny Cooke, Chris Beasley, Stephanie Key, Jill Miller, Jillian and Val Tidswell and Diana Kemp.